Key model of diabetes drug development
Diabetes mellitus is a chronic disease marked by hyperglycemia, triggered by absolute or relative insufficiency of insulin secretion and impaired utilization. The disease is mainly categorized into three types: type I, type II and gestational diabetes. In addition, patients with a long course of the disease may cause chronic progressive lesions, functional decline or even failure of tissues and organs such as the eyes, kidneys, nerves, heart and blood vessels, as well as acute severe metabolic disorders.We have established stable models of type I and type II diabetes, which are suitable for preclinical diabetes drug research and new drug evaluation.
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Disease name | Model name | Animal species |
Diabetes | Db/db mouse model of type II diabetes | mouse |
Type I diabetes model induced by streptozotocin (STZ) | rat | |
Type II diabetes model induced by high-fat diet+streptozotocin (STZ) | mouse，rat，cat | |
| ZDF rat diabetes model | cat | |
| Combined splenectomy+partial pancreatectomy+glucocorticoid induced type II diabetes model | cat |
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Mouse model of diabetes
