KCI·KMQ has established an anti infection research and service platform with dual qualifications of BSL2 and ABSL2. The BSL-2 laboratory covers an area of approximately 200m ² and includes cells, viruses, and bacteria; The experimental area of ABSL2 is about 1000m ², including 300m ² for small animal laboratory and 700m ² for large animal laboratory. This platform is equipped with a professional operation and technical team, including senior scientists, dedicated laboratory personnel, dedicated veterinarians, and a QA management system. The staff have received special training in professional operations, obtained relevant qualifications, and carried out related work under the guidance and management of scientists with experience in anti infection research and development.
After nearly 2 years of internal research and development and external services, this platform has completed the filing of more than 70 pathogenic microorganisms, successfully established more than 20 animal models of viral and bacterial fungal infections, and has cooperated with more than 20 new drug research and development enterprises in the fields of human vaccines and anti infective drugs, animal vaccines and anti infective drugs, etc., to assist in the development and application of preclinical drugs. At present, the main businesses involved include:
Human vaccines and anti infective drugs, veterinary vaccines and anti infective drugs(1)In vitro anti infective efficacy test:
Antiviral activity - EC50/CC50 detection; MIC drug sensitivity test; FIC measurement; Effects of biological characteristics, etc.(2)Immunogenicity testing of vaccines in vivo: neutralization test, hemagglutination inhibition test, cellular immunity test, etc;
(3)Animal protective testing against viruses: vaccines, antiviral drugs;
(4)Infectious animal testing.KCI • KMQ BioTech Anti Infection R&D Service Animal Model Information List | |||||||||||
category | name | subtype | model | animal species | |||||||
mouse | rat | Cotton Mouse | guinea pig | pig | cat | ferret | rabbit | ||||
virus | Respiratory syncytial virus | A2/ 9320/ 18537 | Attack on Poison Model | √ |
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HBV | B/C/D type | AAV-HBV1.3 infection model | √ |
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influenza virus | H1N1/H3N2/BV/BY | Attack on Poison Model | √ |
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Human herpesvirus 2 (HSV-2) | MS | Reproductive tract infection model | √ |
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Rabbit Papilloma Skin Disease Model | NA | Rabbit CRPV virus skin papilloma |
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Feline infectious peritonitis virus | FCoV II | Cat transmitted abdominal infection model |
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Porcine Blue Ear Virus (PRRSV) | High fever type | Porcine Reproductive and Respiratory Syndrome Virus Infection Model |
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bacteria | Staphylococcus aureus | Seattle 1945 | Skin wound infection model |
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Septicemia model | √ |
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Escherichia coli | Seattle 1946 | Septicemia model | √ |
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Enterobacter cloacae | Clinical strain | Model of thigh muscle infection | √ |
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Baumann Acinetobacter baumannii | Clinical strain | Pneumonia model |
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Model of thigh muscle infection | √ |
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klebsiella pneumoniae | C122 | Infectious pneumonia model | √ |
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Pseudomonas aeruginosa | ATCC9027 | Infectious model of pneumonia | √ |
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Septicemia model | √ |
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Model of thigh muscle infection | √ |
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fungus | Candida albicans | 3147 | Vaginitis model |
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Septicemia model | √ |
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Pneumonia model | √ |
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Aspergillus | Aspergillus fumigatus/ Aspergillus flavus | Pneumonia model | √ |
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In vitro drug efficacy evaluation platform | Isolation and cultivation of bacteria/fungi/viruses | |
In vitro antiviral test | Antiviral drug CC50 and EC50 testing | |
In vitro antimicrobial susceptibility test | Determination of minimum inhibitory concentration (MIC) | |
Minimum bactericidal concentration determination (MBC) | ||
FIC assay chessboard method combined with antibacterial ability determination | ||
Sterilization curve determination (KCs) | ||
Evaluation of vaccine immunogenicity | Humoral immune evaluation: IgG, neutralization test, hemagglutination inhibition potency detection | |
Cellular immune evaluation: ELISPOT and flow cytometry detection | ||
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In vivo drug efficacy evaluation platform | Virus class | Reproductive tract infection |
Respiratory system infection | ||
Skin system infection | ||
Metabolic system infection | ||
Animal or pet infection evaluation | ||
Bacteria and fungi | Reproductive tract infection | |
Respiratory system infection | ||
Skin system infection | ||
Systemic infection | ||
Muscle infection | ||