Key models for drug development in liver fibrosis/cirrhosis
Liver fibrosis is a liver disease with many etiologic factors, and is most commonly seen clinically in viral hepatitis, alcoholic liver, fatty liver, and autoimmune diseases.We have established a stable liver fibrosis/cirrhosis model, which is suitable for preclinical studies and new drug evaluation of drugs for liver fibrosis/hardness.
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Disease name | Model name | Animal species |
Liver fibrosis/cirrhosis | Carbon tetrachloride induced liver fibrosis/cirrhosis model | mouse, rat, non-human primate |
Primary biliary cirrhosis model induced by bile duct ligation | mouse，rat | |
Primary biliary cirrhosis model induced by α - naphthylisothiocyanate (ANIT) | mouse，rat | |
| Primary biliary cirrhosis model induced by 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC) | mouse | |
Carbon tetrachloride induced portal hypertension model in liver cirrhosis | rat |