Key Models for Deep Vein Thrombosis Drug Development

　　Deep vein thrombosis (DVT) is the abnormal clotting of blood in the deep veins and is a disorder of venous return in the lower extremities. Most of the thrombosis occurs in the state of braking (especially major orthopedic surgery). If not diagnosed and treated in time, most of them will evolve into sequelae of thrombosis, which will affect the quality of life of patients for a long time; and some patients may have pulmonary embolism, which will cause extremely serious consequences.
　　We have established a stable vena cava thrombosis model, which is suitable for preclinical research and new drug evaluation of drugs for treating venous thrombosis.
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Disease name	Model name	Animal species
Deep vein thrombosis	Model of inferior vena cava thrombosis caused by transient blood flow occlusion	mouse,rat,rabbit
	Thrombin-induced thrombus model of the inferior vena cava	mouse,rat,rabbit
	Femoral vein thrombosis model	mouse,rat,rabbit
	Collagen + epinephrine - induced a pulmonary artery thrombosis model	mouse
	Thrombin - induced pulmonary artery thrombosis model	mouse
	ADP - induced pulmonary artery thrombosis model	mouse

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